JoNova

A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).


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Vitamin B6 may reduce the cytokine storms of Covid

Maybe getting enough Vitamin B6 will reduce deaths

The main two things that kill people with Covid are blood clotting and an out-of-control inflammation known as a cytokine storm. A group of researchers noticed that both of these were things Vitamin B6 was known to reduce — blood clotting, and inflammation. In particular, there’s a molecule called Interleukin 6 which is a “masterplayer” signal in our immune system and — what do you know — B6 reduces it. Mice that weren’t fed enough B6 got mouse pneumonia more than mice who were fed enough. B6 is anti-inflammatory, anti- and reduces reactive oxygen species (ROS).

The Big Black hole in medical research?

I hoped this paper was report on experiments with Covid patients, but the paper and press release is essentially a literature review of many pre-covid studies and a plea for research into whether vitamin B6 might help stop the deadly cytokine storm.

The bigger, global question they don’t ask, is why despite the millions (billions) going into vaccine design and drug research, hardly anyone is studying the cheap unprofitable and obvious questions? Perhaps we need some government funded research that’s not driven by profits… oh. wait.? What happened to […]

Asthma drug Budesonide reduces Covid hospitalization rate dramatically

The STOIC study gave an asthma drug to Covid patients, but it worked so astonishingly well, they had to stop the trial early, as it was unfair to keep giving the placebo to people who were ending up in hospital ten times as often as people who got Budesonide.

“We were hoping for 50% reduction [in severity]. We got 90%, which … is off the charts”

–h/t Eric W at WUWT

Though to keep some perspective, out of about 140 people enrolled, 70 got the drug and 70 got the placebo, with 10 of the placebo group going to hospital and only 1 in the Budesonide group.

You’ll be shocked to know that giving the drug early works better than waiting for the virus to replicate wildly. You’ll also be shocked that there were some doctors using this 7 or more months ago, and yet the media didn’t mention it Apart from Newsmax. (Eg See Dr Richard Bartlett talk about this back in July last year, who talks of using a nebulizer, not an inhaler. )

Common asthma drug slashes Covid hospitalisation by 90%, experts say

Vanessa Chambers, The Sun

A […]

In Peru, Ivermectin cut covid deaths by 75% in 6 weeks: cheap, safe and quite ignored

How many unnecessary deaths does it take til people get angry? Angry that the Chief Medical Officers and Health Ministers didn’t ask for studies to be done. Angry that most academics sat by and said nothing. And angry that the media just parroted the institutions.

One good antiviral changes everything. If the world had a safe cheap drug, we could not only reduce deaths and disability, but also slow the rate of mutation down and probably slow the appearance of new mutations down.

The Chamie-Quintero study from Peru shows the West could be only weeks away from reducing the Covid death toll if we used the safe cheap sheep-dip, lice-killing Ivermectin like less wealthy countries do.

A study across the states of Peru found that after Ivermectin was introduced, deaths started to fall about 11 days later, and within a month after that, deaths were down around 75%.

Ivermectin is a drug so useful early researchers got a Nobel Prize in Medicine for work on it. It’s so well known that in the last thirty years more than 3.7 billion doses of Ivermectin have been given out. It’s so safe we can use it on cats […]

Paralyzed mice walk again after just a few weeks

We all could use some good news, and this is quite extraordinary.

“Using gene therapy, a research team has succeeded in getting mice to walk again after a complete cross-sectional injury. The nerve cells produced the curative protein themselves.”

The Town Mouse and The Country Mouse both like this news. | Illustrated by Milo Winter

Normally spinal cord damage is pretty much permanent. Even though we all still have the same genes that built the nerves in the first place, no one seemed to have the right reboot code that could switch on the correct genes in the right order to do the repair. And to give you some idea of the complexity of this, in 2018 a different team estimated that as many as 580 genes may be involved in axon regeneration.

Plenty of researchers have been tapping on the windows and doors of the Nerve Regrowth Holy Grail. This time, instead of just regenerating a nerve in a petri dish, or even even a live animal, they’ve gone a leap further. These mice could walk again.

And all it took was a single injection? “This was a great surprise to the researchers”.

Junk study on Vitamin D shows nothing much but how bad science reporting is

The Sunlight Vitamin

UPDATED! Mea Culpa from me. The post has been corrected*. Thanks to Rob.

__________________

More junk reporting from the Australian government broadcaster the ABC which just copies the junk science press release. Is this what we pay $1b a year for?

The Journalists missed the key factor which was blood levels of participants.

The headline says Clinical trial finds vitamin D does not ward off colds and flu but all it really shows is that in a group that already have *normal, non-deficient levels* of Vitamin D, taking big doses of Vitamin D once a month won’t will raise your blood levels — but won’t make a big difference to your risk of respiratory infections. And it only applies to people aged 60 -74.

Most participants in the study had a normal but sub-optimal Vit D levels and after five years of sporadic high doses, were raised to optimal levels at the end.

After taking 60,000 IU each month, supplementers apparently went from having 77.5 nmol/L up to 114.8 nmol/L,. To put this in perspective, normal levels of Vitamin D start at “50” and above, and there are professors who point out that there are […]

Where are the deaths? Ten reasons the first and second Covid waves look so different

In Europe the second wave is setting new records for daily cases but not for deaths so far (thankfully). So the big question is whether this will stay the same or follow the case tally up.

It’s probably not an accident that infections are spreading fast in mid October. Not only was it late summer in Europe, but the virus has been spreading mostly through 15 to 24 year old healthy young people and when Vitamin D levels were high. But as the Northern Hemisphere tracks away from the Sun, vitamin D levels are falling, temperatures are dropping, and the sterilizing rays of ultra violet grow weak. And, as the days grow colder people gather indoors too. Viral doses are rising.

The enduring scandal of the epidemic is that there are so many ways to treat this virus but they’re not expensive enough for the TGA to recommend them. ;- )

Lots more cases but not many deaths

Exhibit One: The United Kingdom

Some people have used this graph to claim the virus poses no threat. But it isn’t that simple.

UK New cases and Worldometer Deaths graph. (Click to enlarge)

Ten reasons death rates were lower in Europe’s […]

The Doctors who still haven’t recovered from a likely bioweapon

Coronavirus is both the rock and the hard place

There are costs to stopping it, and costs to letting it go. There are businesses that won’t recover, and also people that won’t.

There is much more to pandemic decisions than just “deaths per capita”. One more aspect of the wicked dilemma are “long haulers” or the condition called “long Covid” (which is defined as being ill for 3 months or longer).

Thirty-nine UK doctors who caught Covid are still struggling 6 months later, and have written a joint letter for the British Medical Journal. These were mostly fit youngish people, and they didn’t get hospitalized. They had mild moderate cases of Covid. But many of them say that the after effects are worse than the initial infection. These include things like headaches, dizziness, the inability to walk 200 metres or more, breathlessness, strange numb patches, new allergies, difficulty regulating body temperature, ongoing diarrhea. Many are unable to work.

The cause could be nerve damage, or an autoimmune disorder (or something else entirely). If the virus triggers an immune reaction against their own cells it may be difficult to undo or “grow out of”. Some nerve damage will repair. Some won’t.

[…]

Victoria: it’s democracy and medical science, and getting better fast

The good news: Lockdowns will end sooner than expected. Not soon enough for some desperate businesses, but sooner than Dan Andrew’s modelers thought.

As I predicted, Victoria is doing better than the models estimated. Many people focus on the “daily new cases” but the “unknown source cases” is a better, more forward looking tool.

In Newspoll today we find — also as I predicted from the outset of the pandemic — that health is priority one for most voters. It’s an awkward fact of democracy. As drastic as the restrictions are in Victoria, more than half the voters are happy to give up some freedom temporarily in order to save lives, hardship and unknown health effects, and the burden on healthworkers.

Right-leaning small business owners and entrepreneurs are often not at all happy about giving up freedom. They’re much more comfortable taking risks, but most of the population are not. It’s a personality type thing. It’s not going to change. (What’s obscene though, is that those comfortable taking risks are bearing more of the costs while public servants like Dan Andrews are getting fat pay rises. )

Despite the strict restrictions, fully 71% of Victorians view the restrictions as “about […]

Good news: masks, means more asymptomatic infections and less severe ones

It appears people who wear masks are much less likely to get severe infections

This will make some heads spin.

Child Wearing a a Mask. Author vperemen.com

Not only do masks reduce the odds of getting infected, but if people do get infected while wearing a mask — the severity of Covid is so much milder. With masks on, the odds of getting an asymptomatic infection improve. Masks don’t stop all viral particles but they stop the large droplet clusters, and thus reduce the viral load. If asymptomatic people get some protection (and we still don’t know for sure) it could solve so much.

Consider the two cruise ships where the asymptomatic rate varied from 18 to 81%:

One used masks and one didn’t:

In February, one of the first outbreaks of COVID-19 outside of China occurred on the Diamond Princess cruise ship docked in Yokohama, Japan. Of the 634 people on board who tested positive, about 18 percent of infections were asymptomatic. In March, an Argentinian cruise ship found itself in a similar predicament, but of the 128 people on board who eventually tested positive, 81 percent were asymptomatic— Ghandi et al.

Nations that use […]

How to ignore 94% of Covid deaths?

Be wary of junk data and junk conclusions

Death data has become a political tool (stretched both up and down by vested interests). We’ve all heard of the motorcyclist who crashed into the Covid tally, and the payments for US docs. We know there’s junk data out there, but the suggestion we only count deaths “from” Covid, and not the deaths “with” Covid is unscientific in the extreme.

Stick with me. We all want WuFlu to be nothing, but scientists and skeptics need to pick their targets carefully. Don’t lose sight of the real scandal and the real solutions. It’s a travesty that people are dying while cheap vitamins and antivirals are being ignored. Let’s fight for Vitamin D, HCQ, Ivermectin, and all the other potentials like Interferon, Bromhexine, Melatonin, steroids, asthma drugs etc etc. But let’s not get distracted by a hopeful fantasy that the true US “death tally” is only 6% of Covid deaths in the US.

There’s an idea out there that only 9,680 people have died of Covid in the US, not 161,392 people. It’s because of this CDC quote:

“For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with […]