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Mutations of SARS2 are roaming. Currently there are 19 million active (known) cases of Covid. Due to copying errors, mistakes are accumulating in the genes of the virus. It’s a relentless process of trial and selection. A trillion monkeys on keyboards blindly working its way around vaccines, and immune systems. To beat this, we need to understand it.
Below is a map of known variants created from the samples which have had full sequences done. This is the remarkable “Nextstrain“ — an opensource tool. I have labelled a few clusters by their “country names”, (though we’re not supposed to do that. Let’s all say “WuFlu”.)
The family tree of SARS-Cov-2 starts at the bottom left corner with two samples from Wuhan around Christmas 2019. This is called the 19A clade, which appears to have almost died out now, though there are still remnants left of this original virus in corners like Iran and PNG. Otherwise, the Wuhan 19A virus has been superseded by its children.
The branches and time marches to the right.
Nextstrain: Latest global SARS-CoV-2 analysis
The code for one full virus is 29,000 bases long and as best as I can tell, all the dots […]
The CCP is still not being honest about bioweapons research in China. How stupid does the West have to be?
The The Mail on Sunday has documents showing that the Wuhan Institute of Virology was working with the Chinese military on a big project to study animal viruses that started in 2012.
The title of the project was ‘the discovery of animal-delivered pathogens carried by wild animals’. The man in charge was Xu Jianguo. In 2019 he was heard bragging at a conference that “‘a giant network of infectious disease prevention and control is taking shape’.” He was part of the first expert group called in to deal with Covid in January 2020 and was the one who denied human transmissibility. In mid-January he said that the “epidemic is limited and will end if there are no new cases next week”.
Well that was helpful.
The group had five leaders — one was Professor Shi Zhengli who works in the Wuhan Institute of Virology, is known as the “bat woman” for her work hunting in caves for bat viruses. Only last month she denied that there was any military involvement. But one of the other leaders was Cao Wuchun, […]
There are lessons for conservatives from this eclectic election in the most isolated state on Earth. It was historic, epic, and “A complete and utter landslide“. And the message is “borders”. Remember “Build the Wall?” Conservatives all around the world seem to have forgotten the power and appeal of being able to control who and which viridae, come across the border. If the Democrats in the US fortified the wall, they might not have to fortify election results.
It’s a complete blitz. | The West Australian
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The election Saturday was a wipeout of legendary proportions among democracies anywhere. Only four years ago, the Liberals (conservatives, theoretically) were the ruling party in Western Australia. Today they hold but two, as in one plus one, seats in the lower house of the WA Parliament, out of 59. They may win 3. The Labor Party took 58% of the first preference votes (that’s almost unheard of). Labor will take the Upper House too. See: WA Election Results. Things are so extreme, the talk now is how the Parliament is not big enough to hold the Labor M.P.’s. The rooms are just not designed for one party having almost […]
How many unnecessary deaths does it take til people get angry? Angry that the Chief Medical Officers and Health Ministers didn’t ask for studies to be done. Angry that most academics sat by and said nothing. And angry that the media just parroted the institutions.
One good antiviral changes everything. If the world had a safe cheap drug, we could not only reduce deaths and disability, but also slow the rate of mutation down and probably slow the appearance of new mutations down.
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The Chamie-Quintero study from Peru shows the West could be only weeks away from reducing the Covid death toll if we used the safe cheap sheep-dip, lice-killing Ivermectin like less wealthy countries do.
A study across the states of Peru found that after Ivermectin was introduced, deaths started to fall about 11 days later, and within a month after that, deaths were down around 75%.
Ivermectin is a drug so useful early researchers got a Nobel Prize in Medicine for work on it. It’s so well known that in the last thirty years more than 3.7 billion doses of Ivermectin have been given out. It’s so safe we can use it on cats […]
Some things matter. The biggest scandal of Covid — the one worth fighting for — is that there are drugs that work, which are safe and well tested, but they suffer from the crippling problem of being too cheap for our captured public health institutions to use. Because they are old safe, mass produced and out of patent no Pharmaceutical giant will make mass profits, which dooms them to being ignored, under researched, and generally scoffed at in rude dismissive terms.
The biggest failure of our government health agencies right now is the Black Hole of Medicine — the astronomical event horizon beyond which cheap safe drugs disappear without a trace.
3,000 people are dying every day in the USA and 5,000 a day are dying in Europe, mostly from a problem which can be solved to a large extent.
Sure, the media hate HCQ because “Donald”. But it’s not just HCQ and it’s not just Trump — the media ignore all the cheap antivirals and all the rich nations have the same medical Black Hole. This is the work of the Medical Swamp, captured by Big Pharma.
The Age of Antivirals is here and hardly anyone even knows […]
In Europe the second wave is setting new records for daily cases but not for deaths so far (thankfully). So the big question is whether this will stay the same or follow the case tally up.
It’s probably not an accident that infections are spreading fast in mid October. Not only was it late summer in Europe, but the virus has been spreading mostly through 15 to 24 year old healthy young people and when Vitamin D levels were high. But as the Northern Hemisphere tracks away from the Sun, vitamin D levels are falling, temperatures are dropping, and the sterilizing rays of ultra violet grow weak. And, as the days grow colder people gather indoors too. Viral doses are rising.
The enduring scandal of the epidemic is that there are so many ways to treat this virus but they’re not expensive enough for the TGA to recommend them. ;- )
Lots more cases but not many deaths
Exhibit One: The United Kingdom
Some people have used this graph to claim the virus poses no threat. But it isn’t that simple.
UK New cases and Worldometer Deaths graph. (Click to enlarge)
Ten reasons death rates were lower in Europe’s […]
Another day in the strange world of Covid
A new finding suggests Covid-19 doesn’t just bind to the ACE2 receptor, it also binds to a key pain receptor called neuropilin-1 receptor (NRP-1). This could explain why some people with a high viral load are asymptomatic and infectious but unaware they are unwell. It’s like the virus is arriving with it’s own morphine. In theory this might be a successful adaption from the virus’s point of view as it may increase the spread of the disease if infected people wander around able to shed virus for longer.
Despite being fed up with the WuFlu, the efficient perfidy is something to behold (at least to a microbiologist). It’s like a pocketknife.
On the down side, the virus may still be damaging tissues in this painless state, which might explain some of those findings of lung and heart damage even in mild or asymptomatic cases.
There is at least one potentially very nice payoff. The finding from the University of Arizona, may lead to the design of whole new painkillers based on the coronavirus spike that is “better than opioids”. The lead author says he has been contacted by people who had […]
Dr Li-Meng Yan worked in the WHO Coronavirus Reference Lab in Hong Kong. She has just published a detailed paper claiming that the SARS-2 coronavirus was artificially made in a laboratory and appeared on Tucker Carlson’s show today. She also claims it was deliberately spread (though this was slightly ambiguous– listen closely).
We already had enough evidence to know that SARS-Cov2 is a likely bioweapon. (The virus it supposedly evolved from appears to be fake.) This is largely what her paper covers.
Chinese defector virologist Dr Li-Meng Yan publishes report claiming COVID-19 was made in a lab
Phoebe Looms, News.com
Dr Yan had been working at Hong Kong University’s public health laboratory sciences division, a World Health Organisation infectious diseases research centre, when her boss was asked to investigate the outbreak in Wuhan.
Dr Yan claimed her and her team’s scientific findings were suppressed, and they were told only to report cases linked to the Huanan seafood market. After becoming fearful of her safety, she fled China on a flight bound for Los Angeles in late April.
Others in her lab said: “ Dr. Yan’s statement does not accord with the key facts […]
All around the world are dawning headlines wondering if we have founds signs of life on Venus.
Despite the hunt for life on star systems that are lightyears from Earth, it turns out there may be something on the Planet-next-door. “May” being the operative word. A team found phosphine in the atmosphere of Venus and can’t think of any other way it could have got there. Phosphine is considered to be a biomarker. And microbes on Earth would have no trouble making it, though none of them could easily survive on Venus where the atmosphere clouds and rain are nearly pure hot sulphuric acid.*
Scientists find gas linked to life in atmosphere of Venus
Ian Sample, The Guardian
Sara Seager, a planetary scientist on the study at MIT in the US, called the finding “mind-boggling”. She hypothesises a lifecycle for Venusian microbes that rain down, dry out and are swept back up to more temperate altitudes by currents in the atmosphere.
For 2bn years, Venus was temperate and harboured an ocean. But today, a dense carbon dioxide atmosphere blankets a near-waterless surface where temperatures top 450C. The clouds in the sky are hardly inviting, […]
It appears people who wear masks are much less likely to get severe infections
This will make some heads spin.
Child Wearing a a Mask. Author vperemen.com
Not only do masks reduce the odds of getting infected, but if people do get infected while wearing a mask — the severity of Covid is so much milder. With masks on, the odds of getting an asymptomatic infection improve. Masks don’t stop all viral particles but they stop the large droplet clusters, and thus reduce the viral load. If asymptomatic people get some protection (and we still don’t know for sure) it could solve so much.
Consider the two cruise ships where the asymptomatic rate varied from 18 to 81%:
One used masks and one didn’t:
In February, one of the first outbreaks of COVID-19 outside of China occurred on the Diamond Princess cruise ship docked in Yokohama, Japan. Of the 634 people on board who tested positive, about 18 percent of infections were asymptomatic. In March, an Argentinian cruise ship found itself in a similar predicament, but of the 128 people on board who eventually tested positive, 81 percent were asymptomatic— Ghandi et al.
Nations that use […]
Be wary of junk data and junk conclusions
Death data has become a political tool (stretched both up and down by vested interests). We’ve all heard of the motorcyclist who crashed into the Covid tally, and the payments for US docs. We know there’s junk data out there, but the suggestion we only count deaths “from” Covid, and not the deaths “with” Covid is unscientific in the extreme.
Stick with me. We all want WuFlu to be nothing, but scientists and skeptics need to pick their targets carefully. Don’t lose sight of the real scandal and the real solutions. It’s a travesty that people are dying while cheap vitamins and antivirals are being ignored. Let’s fight for Vitamin D, HCQ, Ivermectin, and all the other potentials like Interferon, Bromhexine, Melatonin, steroids, asthma drugs etc etc. But let’s not get distracted by a hopeful fantasy that the true US “death tally” is only 6% of Covid deaths in the US.
There’s an idea out there that only 9,680 people have died of Covid in the US, not 161,392 people. It’s because of this CDC quote:
“For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with […]
I didn’t think cough syrups even worked against coughs, but one new paper suggests that bromhexine in common cough syrups reduces both Covid-19 rates of ICU and of mortality.
The era of antivirals has come, not that Big Pharma want you to know that cheap out-of-patent drugs might help. But for years we were told that medical science didn’t have an answer to viruses.
Bromhexine was patented in 1961 and is commonly found in OTC pharmacy cough syrups with names like Bisolvon, Robitussin, and Duro-Tuss (Wiki has a long list).
Theoretically Bromhexine sabotages one of our molecules — with the snappy name of TMPRSS2 (which is shorter than saying Transmembrane protease S2). A protease is a fancy pair of molecular scissors, it chops or tweaks the viral spike and if that doesn’t happen, the virus can’t get into the cell (at least not through its favourite path).
The nice thing about an antiviral acting against our molecules, rather than against the virus itself, is that it’s harder for the virus to mutate to get around it. That means it’s less likely the virus can develop resistance. The downside of targeting our own molecules is that it might fritz things up. […]
The first case of a definitive reinfection was reported today
Before we look at whether a cold gives us protection let’s point out we don’t know how well a SARS 2 infection gives us protection.
A 33 year old man in Hong Kong was tested positive nearly five months after his first infection, and with a slightly different variant of the virus, so it’s very likely this was a second infection rather than a resurgence of the first. It hints that Covid may be a bit like the common cold, and our immunity may be partial and temporary which is not good news for the herd immunity idea and the vaccine plan, but it’s only one case. On the plus side, he had a three day fever, cough and sickness in March, but is asymptomatic this time, suggesting that maybe there is enough residual immunity to help him beat the second infection.
There have been other reports of people getting reinfected but none of the previous cases had genetic testing of both infections to show they were different. But 13% of 4,000 doctors who were surveyed in May (even at that early stage) believed that at least one of their […]
Lessons from Coronavirus
Lockdowns and border closures mean many diseases have been prevented
It’s peak season for flu here in Australia and there’s almost no sign of it. As Chris Gillham wrote here back in May, we know lockdowns stop viruses, because flu cases are 85% down. Now he shows that this extends to other diseases too, and Chris has used data from the National Notifiable Diseases Surveillance System to calculate that just shy of 200,000 fewer Australians contracted any of the notifiable diseases in the first seven months of 2020 compared to the first seven months of 2019.
Is some of that disease burden just the price of holiday-makers bringing back diseases from overseas each year?
No one wants to stop the planes returning to the skies, but it begs the question — do we have to accept the onslaught of winter germs every year?
The answer may lie with other things we’ve discovered in the Covid pandemic too — that sick people should stay home from work and school, and that we have a lot of anti-viral tools we can use. Perhaps it’s time that travellers considered taking preemptive anti-virals, which might improve their holidays and also reduce […]
The scandal from the Swamp: Too rich to get a cheap drug?
Poor countries all over the world are using Hydroxychloroquine (HCQ) and it appears to be very useful.
The new HCQTrial suggests that despite the billion dollar budgets and expert staff, people in wealthier countries are dying from Coronavirus at far higher rates than people are in lands where HCQ is being used. And the effect of HCQ apparently holds even after researchers correct for patients being older, heavier, with higher blood pressure, living in high density apartment towers, or with getting tested more.
If word ever gets out that the Politico-Academic-Corporate-Swamp buried useful drugs because they were unprofitable and out of patent, there will be hell to pay.
The HCQTrial was done anonymously by @CovidAnalysis — who say they are PhD researchers, scientists.
You can find our research in journals like Science and Nature. For examples of why we can’t be more specific search for “raoult death threats” or “simone gold fired”. We have little interest in adding to our publication lists, being in the news, or being on TV (we have done all of these things before but feel there are more important things in […]
Do 10,000 extra infections matter?
JoNova — cheaper and faster than a Parliamentary Report — said two months ago that it was baffling that the UK locked everyone down, but kept flying in the virus. Now British MP’s are saying the same.
UPDATE: Given Boris Johnson suddenly changed policy on flights from Spain last week, immediately adding a mandatory quarantine, what’s the bet someone told him this report was coming?
No 10’s ‘inexplicable’ decision to lift quarantine at height of pandemic: MPs’ damning report condemns ‘serious mistake’ that allowed 10,000 infected people into the UK
David Barett, DailyMail
Delaying quarantine measures at the border was a ‘serious mistake’ that allowed 10,000 infected people into the UK accelerated the virus spread, a major report by MPs says.
The cross-party inquiry is highly critical of the Government’s ‘inexplicable’ decision to lift its initial quarantine measures in mid-March, ten days before lockdown.
Experts from the London School of Hygiene and Tropical Medicine calculated that up to 10,000 infected people, largely from Spain, France and Italy, imported the virus into the UK.
Viruses can only survive in people temporarily, so to beat a rogue chemical […]
No wonder the Chinese lockdown a million people with every outbreak. Two thirds of these cases were not hospitalized.
These studies are small and need confirmation, but the medical specialists are asking if it is possible that Covid infections create new cases of heart failure which may trigger problems long after infection?
A startling number of COVID-19 patients suffer lasting heart damage
Fermin Koop, ZME Science
A study from the University Hospital Frankfurt looked at the cardiovascular MRIs of 100 people who had recovered from the coronavirus and compared them with heart images of people who hadn’t been infected.
Most of the patients hadn’t been hospitalized and recovered at home, with symptoms ranging from none to moderate. Two months after recovering from COVID-19, the patients were more likely to have troubling cardiac signs than people in the control group. Up to 78% of them had structural changes to the heart, while 76% had evidence of a biomarker signaling cardiac injury typically found after a heart attack, and 60% had signs of inflammation.
The Puntmann study was based in Germany, and the average age of cases was 49. Troponin is a marker used in standard […]
New research shows that families with teenage children were three times more likely to get Covid (odds of spread , 18%) than families with children under ten (5%). It appears that it’s more dangerous to live with teens than to live with adults (12%). It may be that teens are more likely to be asymptomatic which means people don’t realize they need to isolate from them.
The question of opening primary schools is potentially very different to high schools. Quite possibly puberty affects immune systems in ways that make teens effectively young adults.
Older Kids May Transmit COVID-19 as Much as Adults Do, New Evidence Shows
ScienceAlert
The results also showed up something unexpected, however. When index patients were categorised by age (0–9, 10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, and >80 years), households with older children (index patients of 10–19 years) had the highest rate of infection spread to household contacts, with 18.6 percent of household contacts later showing the infection.
By contrast, young children (index patients 0–9 years of age) seemed to confer the least amount of spread of the virus, with just 5.3 percent of household contacts contracting the infection, which […]
Welcome to the Era of the Anti-Virals. They’re everywhere.
A legacy of the coronavirus pandemic is the dawn of new ways to stop viruses. Here’s another new (old) one — it’s only a small trial, but if it can stop 4 out of 5 people developing the severe form of the disease it will be a gamechanger. If this gets similar numbers on larger trials, then we still need mass production. But national policies will swing on a dime if a safe drug with this much potential appears.
After Coronavirus we might not be so content to accept the annual seasonal virus scourge.
Postenote: These are preliminary results, not a large trial, but at least it is placebo controlled and randomized.
Breakthrough’ treatment slashes virus death risk: study
by Patrick Galey, MedicalXpress
In a randomised trial of 100 patients admitted to hospital with COVID-19, those who received an inhaled formula of the protein interferon beta were at 79 percent lower risk of developing severe disease compared to those who received a placebo.
They were also more than twice as likely to make a full recovery compared with the control group.
The firm […]
Scott Morrison says eliminating the virus is not viable, despite most states in Australia effectively managing to do that already. See the chart below. Instead he talks of suppression as if it’s viable to ride an exponential curve with a default position of “moonshot”.
At the start of June, Victoria was getting 20 new cases a week. In the last three weeks Victoria has added 3,000 cases.
State premiers are being urged to reject an elimination strategy for coronavirus, with Scott Morrison and leading business groups warning the move would double unemployment and wreck the economy.
The Prime Minister, who has conceded the lockdown of Greater Melbourne was necessary given the size of the outbreaks, warned that any pivot to an elimination strategy would double unemployment.
Suppression sounds like a management plan but means rolling waves of infection and isolation, with outbreaks of chaos and a constant higher level of fear and avoidance. This does not seem like a jobs creation machine.
Would we prefer one lockdown or three?
1. The hospitalization rate means hospitals will be overwhelmed within weeks (see Victoria). Therefore repeat lockdowns are inevitable.
2. It’s hard to protect […]
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JoNova A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).
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