The peer review system has decayed to the point where the culture of the two “top” science journals virtually guarantees they will reject the most important research done today. It is the exact opposite of what we need to further human knowledge the fastest. Science and Nature are prestigious journals, yet they are now so conservative about ideas that challenge dominant assumptions, that they reject ground-breaking papers because those papers challenge the dominant meme, not because the evidence or the reasoning is suspect or weak.
Watts Up drew my attention to an extraordinary paper showing that billions of dollars of medical research may have been wasted because researchers assumed mice were the same as men. Dr Ronald W. Davis from Stanford comments: ““They are so ingrained in trying to cure mice that they forget we are trying to cure humans.” He found that 150 drugs were tested that in hindsight, were guaranteed to fail in humans. People didn’t understand that mice have a very different response to sepsis (which is any overwhelming blood-borne bacterial infection). Sepsis kills around 200,000 people in the US each year and costs an estimated $17 billion a year. Mice are already resistant to huge numbers [...]
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