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Here’s a tantalizing bit of gene research. Scientists were able to switch off a central gene in the nucleus of a mouse cell. That in turn meant the mouse’s mitochondria started failing (I’m going to be talking a lot more about these fascinating bits of machinery in our cells). After two months, the poor lab mice were wrinkled, going bald and their organs were aging rapidly, but lo, after the gene in the nucleus was switched on again, the mitochondria were restored, and wow, all the hair and skin grew back to what it had been before.
Mitochondria have their own DNA loops.
Why get excited about mitochondria? These are tiny biological batteries we have inside every cell. The are the mini-factories burning sugar or fat, generating free radicals on a mass scale and churning out the chemical energy that is then used in most of the chemical reactions in our body. They are turning up in every second paper these days related to aging. These little organelles are so important and rule breaking they even have their own DNA loops with 37 genes — this is the only genetic material in us that is not part of the […]
It’s another warmy story:
Worst year in NSW for Salmonella, E.Coli as global temperatures increase
NSW recorded its worst figures in at least five years for diseases caused by food poisoning and mosquito bites, as doctors warn climate change is looming as a public health emergency.
Statistics released last week show 2016 was the worst year on record for diseases including legionnaires’ disease, salmonellosis, listeriosis, E. coli and dengue fever, which flourish in warmer conditions.
–-Harriet Alexander, Sydney Morning Herald
More scary than 4000 cases of salmonella is the state of intellectual rigor among medico-unions:
The Royal Australasian College of Physicians [RACP] has released a position paper that described climate change as a “global public health emergency”.
The RACP called for a national climate and health strategy and reduced emissions of greenhouse gases.
With reasoning like that, they could make a lot more people very sick. Are they advocating we use solar panels to stop salmonella?
There has hardly been any warming in the last 20 years anyhow. And if we are doing cosmic epidemiology, so far global warming seems to come with longer lifespans, health, wealth, food, […]
Bacteria multiply
In the West we could try to cure cancer faster with research like this, or we could pour billions into making expensive electricity to try to cool the world by 0.01°C for our grandchildren. Hmm. What to do? Which activity is more likely to make citizens richer, happier and more productive?
In this approach (below) bacteria are engineered to find cancer cells, make lots of baby bacteria until they reach a large enough colony size then do a mass self-destructo at the cancer site — releasing a tumor killing drug. A few bacteria survive the micro-apocalypse and they start another round. So far, the researchers haven’t cured any cancers, but they can shrink cancers in mice and extend mousy lives by 50%. One day this might mean cancers can be “lived with”, if not actually destroyed completely.
A critical mass is reached and the colony “bombs”.
So the bacteria can be engineered into neat little machines to manage cancer. But they are still living creatures, so are messy machines. One problem is that evolution tends to make all living machines chuck out bits of DNA that don’t improve survival, so the “survivors” will gradually take over, […]
Why are we still wasting money trying to change the weather?
We’ve cracked the code to program biology and there are so many better things we can do. We can read the four letter alphabet, and now we’re in the early days of unpacking the operating systems. One team (below) has just reprogrammed skin cells to hunt down one particular type of brain cancer and found a way to get the cells to stick around long enough to deliver killer drug doses to the cancer cells. It’s at proof of concept stage — we can extend the life of mice with this cancer by about 200%, but we haven’t tried this in people. This may be years off, or not. Cancer is an information problem.
In one form or another this concept will change the world. Sooner or later we will figure out how to reprogram cells to seek out and destroy every last difficult-to-get cancer cell. No more mass collateral damage that kills healthy cells too. Then we’ll teach the immune system to stay alert and keep picking off any recidivists. No more recurrences.
This is just the beginning of customized, individualized medicine. Early days.
Groundbreaking discovery made […]
This example below shows the dangers of cherry picked and buried data. It shows how great news and joy can be reported from rancid results, and the only protection against this is open access. When the taxpayer funds research that is not fully and transparently public, and immediately available, the people are funding PR rather than science. “Peer review” does little to stop this, little to clean up the mess after it happens, and the truth can take years to be set free.
Ten percent of teenagers taking an anti-depressant harmed themselves or attempted suicide. This was ten times the rate of the teens on the placebo. The results of this clinical trial were published in 2001, but those alarming statistics were not reported. The drug went on to be widely used. A new reanalysis of the data, reported in the BMJ, revealed the dark and hidden dangers. The company that funded the research, Glaxo Smith Kline, has already faced record fines of $4.2 billion. The Journal of the American Academy of Child and Adolescent Psychiatry won’t retract the paper.
There are many ways to hide data. In this case, the results of the trial include 80,000 records which were […]
Was that a half-truth or a lie by omission? Trick question…
Malcolm Kendrick reports on a new study that he says should “shake the foundations of medical research” but laments that it almost certainly won’t.
In the year 2000, the US National Heart Lung, and Blood Institute (NHLBI) insisted that all researchers register their “primary aim” and then later their “primary outcome” with clinicaltrials.gov. This one small change in the way medical studies were reported transformed the “success” rates in peer reviewed papers. Before 2000, fully 57% of studies found the success they said they were testing for, but after that, their success rate fell to to a dismal 8%. When people didn’t have to declare what their aim was, they could fish through their results to find some positive, perhaps tangential association, and report that as if they had been investigating that effect all along. The negative results became invisible. If a diet, drug or treatment showed no benefit at all, or turned up bad results, nobody had to know.
The world of peer reviewed climate research: like a universe of dark matter
It’s not like climate science suffers from unpublished “negative results” — no, it’s more […]
by Jo Nova
If the “leech” doctors circa 1000AD were able to treat superbugs that modern doctors struggle with, I wonder what other knowledge has come and gone and had to be rediscovered?
How many lives have been lost because information was not there when they needed it?
Image: © The British Library Board (Royal 12 D xvii)
Judith Curry posted a link this week to a story about a medieval recipe for an “eyesalve” that rather surprised researchers when it worked against the ghastly MRSA superbug, which is resistant to almost all modern antibiotics.
The book is one of the earliest known medical texts, called Bald’s Leechbook. The recipe called for garlic, onion, wine, and bile from a cow. It was very specific — the mix had to be brewed in brass and then left for nine days. The researchers at the University of Nottingham followed it closely, then it was tested in the lab. Will it work on people, and what are the side-effects?
9 out of 10 based on 92 ratings […]
Researchers at Harvard wondered if high risk heart patients were more likely to die if they turned up at the hospital during national cardiology meetings when most of the experts are not around. Instead, it turns out that mortality rates during the conferences fell from 70% to 60%. Oops.
Who do you want to see if you’re sick? In this situation, possibly not your specialist.
High-risk patients with certain acute heart conditions are more likely to survive than other similar patients if they are admitted to the hospital during national cardiology meetings, when many cardiologists are away from their regular practices.
Sixty percent of patients with cardiac arrest who were admitted to a teaching hospital during the days when cardiologists were at scientific meetings died within 30 days, compared to 70 percent of patients who were admitted on non-meeting days.
“That’s a tremendous reduction in mortality, better than most of the medical interventions that exist to treat these conditions,” said study senior author Anupam Jena, assistant professor of health care policy at HMS, internist at Massachusetts General Hospital and faculty research fellow at the National Bureau of Economic Research. There is substantial ambiguity in how medical care […]
The word revolution is overused and done to death. But in the case of medicine, we are in the midst of one. Here are three stories just out this week. It’s possibly none of these will end up being useful clinically, but the sheer volume of results like these mean that sooner or later getting a diagnoses of cancer will mean something very different. It’s time for good news stories. Let’s redirect the gravy train of pointless climate and renewables research. (Sell the ABC and use the money to double our medical research budget. How many lives might we change?*)
These are not instant miracles, but potential ones. The bladder cancer drug ultimately helped about a quarter of all patients. It was a small trial. Two patients of 68 appeared to reach the holy grail: to be tested free of cancer (though it doesn’t mean they are). The second news report talks about a small study targeting a similar mechanism to stop melanoma that only helps about 30% of patients — the study successfully predicted which ones. In both cases the idea is to stop the cancer from hiding from the immune system. Some cancer cells produce molecules called PD-1 […]
The New Yorker has the best article I have read yet on the Ebola outbreak. Finally we get human story and details of how this outbreak started and spread, along with the outstanding heroic efforts of those on the front line. The article has details on everything, the genetics, the virology, the story of escalating fear as health workers started to get infected, and the hard decisions.
Who would get doses of ZMAPP, and which other experimental therapies would be tried? ZMAPP is the genetically engineered copy of antibodies against Ebola, and it does appear to be useful, even though it has not been properly tested. Kent Brantly, the US doctor who contracted Ebola, improved within hours of receiving ZMAPP. His recovery was so fast his medical staff wondered if it were possible, but his colleague Nancy Writebol did not show the same progress.
Know thy enemy: only six proteins and one line of code, yet so incredibly deadly. The virus is not one virus, but a swarm of particles — an evolving population.
Since Ebola makes errors as it replicates, each genome was like a hand-copied text, and detectable differences would emerge among the genomes; there isn’t […]
In case you’ve missed this — stem cells have been used to partially restore movement in a 38 year old man who had his spinal cord completely severed by a knife attack in 2010. The cells came from his nose, and are technically olfactory ensheathing cells (OEC). They are unique cells — the only nerve fibres we know of that grow and make connections with the central nervous system. It’s no magic instant bullet, but a first step. It’s taken 19 months of intensive rehab after the transplant, but he is now able to drive. It’s not known if this procedure can help with paralysis caused by other, more messy causes of spinal breaks. The stab wound was a very clean cut.
It is almost 30 years since Prof. Geoffrey Raisman first identified the potential of OEC’s to repair nerve damage in mice. In November 2012 researchers in Edinburgh were able to restore a dogs ability to move hind legs.
Speaking earlier today Geoffrey Raisman described the results as “more impressive than man walking on the moon”. — speakingofresearch
There are at least three different methods of possibly curing paralysis which have all made announcements this year. In May […]
I am glad that Nigeria is officially free of Ebola now. The story is reassuring. New outbreaks of Ebola are stoppable. But the numbers are sobering. They show how far gone the situation is in West Africa.
The index patient (as the source of the outbreak is known) arrived in Lagos, a megacity of 21 million people, on July 20th — a recipe for disaster. Over the next six weeks 19 further people were diagnosed with Ebola. The death toll was eight people, many of them health workers. Those infected generated 989 contacts, and it took 18,500 in-person, follow up visits to make sure that the virus did not spread further.
Translate those ratios to West Africa, where the latest WHO situation report shows there were 2,638 new cases between September 26 and October 17. In Nigeria, each infected person on average generated 50 contacts, and each contact generated 18 follow-up visits. This is only the roughest of ballpark estimates, but if the ratios were similar, it means that solving the spread in Liberia, Sierra Leone, and Guinea would generate 130,000 contacts and require 2.4 million follow-ups in the next three weeks. By mid November that will double. Obviously things […]
Compare the response of The Firestone Rubber Plantation in Liberia to the Hospital in Dallas, Texas.
The rubber plantation has 8,000 workers with 71,000 dependents. It is an hour north-east of Monrovia, surrounded by Ebola outbreaks. The virus arrived on the plantation in March. Knowing that the UN and the Liberian government were not going to save them, the managers sat around a rubber tree and googled “Ebola” and learned on the run instead. They turned shipping containers into isolation units, trucks into ambulances, and chemical cleaning suits into “haz-mat” gear. They trained cleaners, and teachers, they blocked visitors, and over the next five months dealt with 71 infections, but by early October were clear of the virus. There were only 17 survivors (the same 70% mortality rate as elsewhere). But without good management, there could have been so many more deaths.
In contrast, the nanny-state takes a good brain and stops it thinking. In Texas, trained health professionals were caught unprepared, following inadequate protocols they assumed were good enough, and even risking their own lives. A nurse who cared for a dying Ebola patient — and knew how bad Ebola could be — still needed to phone someone to […]
The bad news –Medecins Sans Frontieres (MSF) said the disease was still out of control. Thanks to the mistake with a plane, a few US schools have closed, and whole neighborhoods are being roped off. How fast does a 19Kb string of information spread? Outside Africa, Norway has one case, Germany has had one death, one survivor, and one case. Spain has lost two, and is treating one. France and the UK have a survivor each. Today, at least, Senegal has been declared free of Ebola.
The WHO organization has admitted it botched the Ebola outbreak in West Africa.
“In a draft internal document obtained by The Associated Press, the agency says “nearly everyone” involved in the response failed to notice the potential for Ebola’s explosive spread.
The agency acknowledged that its own bureaucracy was a problem, pointing out that the heads of WHO country offices in Africa are “politically motivated appointments” made by the WHO regional director for Africa.”
The good news – CSL have said they will develop a plasma product from survivor’s blood. At the moment this is the most pragmatic possible treatment. There are 3000+ survivors who have antibodies, which […]
I’ve been watching Ebola with concern. I hoped we’d have more time. We can still gain control but every week matters. What we do now will be so much easier than what we have to do if we leave it to run.
The summary: The WHO warns that there may be 10,000 new cases a week in West Africa by early December. Can you imagine trying to set up new beds to cope with that each week? Meanwhile the Centre for Infectious Disease Research has advised the CDC that the evidence suggests some airborne spread of Ebola is occurring, which may explain the toll on health workers. Sadly a second health-worker has also been infected with Ebola in Texas (and she was on flight 1143 from Cleveland to Dallas the day before – the CDC wants passengers to call.). Sixteen members of Doctors without Borders have been afflicted, and nine have died. That team deserves medals more help.
There are different versions of airborne infections, hopefully this is in the “only just airborne” category. Just being barely airborne is not the same as, say, being spread like measles. Nonetheless, the game has changed. Healthworkers need even more serious, much […]
I like to keep an eye on research on keeping our brains intact (even if it’s not far past the leeches-and-arsenic stage). Here is a tiny trial showing a bit of promise. After years of testing drugs on Alzheimer plaques without much luck, as far as I can tell, this study had the radical idea of doing a bit of everything that had seemed to delay Alzheimers — like exercise, dumping the carbs, mini-fasts, fish oil, meditation and things like that. Unlike the drug trials, this one actually seemed to work and surprisingly for as many as 9 out of 10 patients (there were only ten patients, that’s not a ratio). It’s quite neat that it did work. It has lots of potential (though not much in the way of profits for big-pharma). However it was only six months long. It may not be slowing the plaques, but then if it restores functional memory, that’s rather the point (though I worry those plaques are coming back later).
Nonetheless, if you like the idea of saving your brain. Worth reading the list below, just so you know and pass it on to those with an interest. Anything that helps, especially when […]
I trained in microbiology so I’ve watched the Ebola situation unfold with quiet dread. When my favourite lecturer was asked what was worst of the worst infectious epidemics he could imagine, he responded that the sum of all fears would be a cross between Ebola and Newcastle’s disease. It would be a highly fatal hemorrhagic disease, combined with a highly contagious virus spread by birds. It’s time to talk of the dark dark possibility that one mutation could bring — the aerosolization of Ebola.
As long as this Filovirus stays in its current form, spread only through direct contact with an infected and obviously ill person, we have a chance to limit the spread. Quarantine is effective. If it goes airborne, the task becomes like preventing the flu, but without clinically tested vaccines, in a totally unprotected population, and with a 60% fatality rate. This is the nuclear option.
The Ebola virus has several different forms, and at least in animal studies, it has “gone airborne” before. Theoretically, it’s an odds game. The more times the virus is copied — the better the odds are that the right mutation will occur. To be brutally blunt, every infected person is another […]
There’s a fascinating study out this week suggesting that if we fast for three or four days a couple of times a year we can regenerate white blood stem cells. Fasting cuts down the number of white blood cells during the fast, but afterwards they recover, and then some.
This new result comes from both mice and phase I clinical human trials. Probably in paleolithic times, famine or at least hungry days were a part of nearly everyone’s life. Many different philosophies and religions have fasting traditions. Apparently our genes are selected to deal with that, and being short of food makes the immune system do a kind of efficiency sweep. Perhaps access to unnaturally continuous food stops our stem cells from reactivating? Something to think about from Killjoy Jo. 😉 Yes, fasting is not exactly fun, but nor is cancer. For what it’s worth, the hard part of a fast is usually the start.
Obviously, consult your doc, do your own research, etc.
The NZ Herald
Fasting for three days can regenerate the entire immune system, even in the elderly, scientists have found in a breakthrough described as remarkable.
University of Southern California
Fasting triggers stem cell […]
Something different to discuss – for the medical-revolution cynics among us. Cells from a human triple-negative breast cancer were implanted in mice under their mammary fat pads. Triple negative breast cancer is a nastier form of breast cancer which is harder to treat because these cells don’t respond to the usual anti-estrogenic drugs.
The mice were then allowed to eat only 70% as many calories as they would normally freely choose to eat. This is a particularly interesting study because it shows that calorie restriction inhibited the expression of certain micro RNAs even from foreign (non mouse) implanted breast cancer cells, and this apparently kept the cancer from spreading. Notably fatalities from cancers don’t usually come from the initial solid tumor but from the metastasized version, so this is potentially very useful.
The mechanism involves strengthening the matrix around the cancer cells. When these cancer cells have metastasized they produce more of these particular micro RNA’s which in turn appear to stop production of proteins that strengthen the extracellular matrix. In other words, the cancer cells probably use the micro RNA’s to degrade the cellular matrix around them in order to spread. The implications of this are both that the […]
Myeloma Cells | Wikimedia
This is another example of why I’m so passionate about getting research money out of dead-end efforts to change the weather and into medical research. The extraordinary news broke last week that the Mayo Clinic had used a genetically modified virus to cure treat one woman of metastasized and widely spread cancer – specifically myeloma. There are a lot of caveats, this research is quite risky, and it doesn’t apply to most people or most cancers, it is a proof of principle.
The potential for transformative medical breakthroughs is spectacular right now. Medicine is, after all, just an information game. The information is expensive but the material resources are dirt cheap — all the answers to the holy grail of the fountain of health are found in rearrangements of common elements — like the kind found in the dirt of a pot-plant. For the first time humanity has the tools to hunt and hammer out the information. If people knew what glittering marvels were within reach, they surely would want to channel our best and brightest and all our spare resources.
The main caveat here (a pretty big one) is that the trial had only […]
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